Effects of Clostridium butyricum on Growth Performance, Antioxidant Capacity, Immune Function and Serum Biochemical Parameters of Broilers
This experiment was conducted to investigate the effects of Clostridium butyricum on growth per-formance, antioxidant capacity, immune function and serum biochemical parameters of broilers.A total of 540 one-day-old Ross 308 broilers were randomly assigned to 3 groups with 6 replicates per group and 30 birds per replicate for a 42-day trial.Dietary treatments were:an antibiotic-free basal diet ( control group, CON) , basal diet supplemented with 10 mg/kg colistin sulfate and 50 mg/kg bacitracin zinc ( antibiotic group, ANT) , and basal diet supplemented with 3×108 CFU/kg Clostridium butyricum (Clostridium butyricum group, CB).The results showed as follows:1) the body weight ( BW) , average daily gain ( ADG) and average daily feed in-take ( ADFI) of broilers in CB and ANT were significantly increased ( P<0.05) compared with those in CON. 2 ) The activities of serum glutathione peroxidase ( GSH-Px) and total superoxide dismutase ( T-SOD) in broil-ers at 42 days of age were significantly enhanced ( P<0.05) compared with those in CON, and GSH-Px activi-ty was 60.00%higher ( P<0.05) than that in ANT.At 7 and 21 days of age, serum T-SOD activity of broilers in ANT was significantly increased ( P<0.05) compared with that in CON.3) Compared with CON, serum immunoglobulin A ( IgA) content in broilers at 21 days of age in CB and ANT was increased by 28.70%( P<0.05) and 26.46%( P<0.05) , and serum immunoglobulin G ( IgG) content in broilers at 7, 21 and 42 days of age was increased by 36.60%( P<0.05) , 37.77%( P<0.05) and 27.03%( P<0.05) , respectively.Serum IgG content of broilers at 7 and 42 days of age in ANT was significantly higher ( P<0.05) than that in CON. Serum immunoglobulin M ( IgM) content of broilers at 21 and 42 days of age in CB was significantly increased compared with CON, while 7.92%( P>0.05) and 47.62%( P<0.05) higher than that in ANT.4) Serum to-tal protein ( TP) content of broilers in CB was significantly higher ( P<0.05) than that in CON, especially in-creased by 31.33%( P<0.05) and 52.27%( P<0.05) compared with that of broilers at 21 and 42 days of age in ANT.Meanwhile, serum ammonia content of broilers in CB was significantly decreased ( P<0.05) com-pared with that of broilers at 21 and 42 days of age in CON.These results indicated that supplementation with Clostridium butyricum in diet can enhance serum antioxidant capacity and immune function, promote protein metabolism, and then improve the growth performance of broilers;moreover, it can aslo reduce ammonia emis-sions from broilers.
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