首页|鱼源抗菌肽的分子设计与优化策略及其应用研究进展

鱼源抗菌肽的分子设计与优化策略及其应用研究进展

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  • 国家科技期刊平台
  • NETL
  • NSTL
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抗菌肽因广谱抗菌性、热稳定性、不易产生耐药性等优点成为极具潜力的抗生素替代物.然而,天然抗菌肽活性差、毒性高、合成成本昂贵等问题限制了其进一步应用.近年来,天然抗菌肽的分子改造与设计成为国内外学者的研究热点.鱼类是天然抗菌肽的重要来源,本文综述了近年来鱼源抗菌肽的作用机制、分子设计与优化策略和在水产养殖中的应用,旨在提供对鱼源抗菌肽的全面了解和认识,为鱼源抗菌肽的开发和应用提供新思路.
Research Progress in Molecular Design and Optimization Strategies of Fish-Derived Antimicrobial Peptides and Their Applications
Antimicrobial peptides are the most promising antibiotic alternatives because of their broad-spectrum antimicrobial properties,thermal stability,and no resistance.However,poor activity,high toxicity and expen-sive synthesis of natural antimicrobial peptides have limited their further application.In recent years,the molec-ular modification and design of natural antimicrobial peptides have become a hot research topic for scholars at home and abroad.Fish is an important source of natural antimicrobial peptides,and this study extensively re-viewed the mechanism of action,molecular design and optimization strategies of fish-derived antimicrobial pep-tides and their applications in aquaculture in recent years,which is aiming to provide a comprehensive under-standing and knowledge of antimicrobial peptides and provide new ideas for developing and applying antimicro-bial peptides.[Chinese Journal of Animal Nutrition,2023,35(12):7541-7551]

antimicrobial peptidesmolecular design and optimizationmechanism of actionapplication

吴迪、王连生

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中国水产科学研究院黑龙江水产研究所,哈尔滨 150070

黑龙江省水生动物病害与免疫重点实验室,哈尔滨 150070

抗菌肽 分子设计与优化 作用机制 应用

中央级公益性科研院所基本科研业务费专项中央级公益性科研院所基本科研业务费专项国家现代农业产业技术体系黑龙江省自然科学基金黑龙江省博士后基金虹鳟鱼病害免疫防控技术研发及应用

HSY202206Q2022XT0402LH-2023C056LBH-Z22297JD22A017

2023

10.12418/CJAN2023.684

动物营养学报
中国畜牧兽医学会

动物营养学报

CSTPCDCSCD北大核心
影响因子：1.297
ISSN：1006-267X
年,卷(期)：2023.35(12)
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