Effects of Plant Polysaccharides on Endoplasmic Reticulum Stress-Mediated Apoptosis,Inflammation and Oxidative Damage of Animal Cells and Their Mechanisms
The endoplasmic reticulum(ER)is an important organelle responsible for protein folding and modi-fication within cells.Endoplasmic reticulum stress is cellular stress response caused by abnormal accumulation of proteins,which can lead to inflammation,oxidative damage and cell apoptosis and other adverse reactions in animal.Recent studies have shown that plant polysaccharides can relieve ER stress through the pathways related to ER overload response and unfolded protein response mediated by ER,thus protecting animal body from inju-ry.This review reviews the mechanism and research progress of plant polysaccharides in alleviating inflamma-tion,oxidative damage and apoptosis induced by ERS in animals.[Chinese Journal of Animal Nutrition,2023,35(12):7641-7647]
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