Biological Functions of Berberine and Its Application in Animal Production
Berberine(BBR)is a common quinoline alkaloid extracted from natural medicinal plants.BBR can be metabolized into a variety of products with biological functions in the intestine,which can promote the repair of damaged intestinal structure,improve the integrity of intestinal mucosal barrier,regulate the structure of in-testinal flora,increase the abundance of intestinal beneficial bacteria,and improve the intestinal environment.BBR can improve the body's immunity by inhibiting the expression of some pro-inflammatory cytokines,and enhance the body's antioxidant capacity by increasing the activity of antioxidant enzymes,reducing the content of malondialdehyde(MDA),activating adenosine 5'-monophosphate(AMP)-activated protein kinase(AMPK)signaling pathway and nuclear factor E2-related factor 2(Nrf2)signaling pathway.BBR can acti-vate ribosomal protein L5(RPL5)-tumor suppressor factor 53(p53)-murine double minute 2(Mdm2)signa-ling pathway to induce nucleolar stress.In addition,BBR can also regulate lipid metabolism,reduce the accu-mulation of fat,and protect the normal structure and physiological function of organ tissues such as liver.In this paper,the biological functions of BBR on animal intestinal structure,intestinal flora,immunity,antioxi-dant and anti-apoptotic ability,induction of nucleolar stress and its application in the production of poultry,pigs,ruminants and other animals were reviewed,in order to provide reference and theoretical basis for the de-velopment and rational application of BBR in animal production.[Chinese Journal of Animal Nutrition,2024,36(1):12-24]
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维普
