摘要
肠道黏膜屏障作为机体与外部环境进行互作的重要场所,可防止肠道内病原微生物和有毒有害物质侵入,其完整性对动物肠道健康至关重要.厚朴酚是我国传统中药厚朴中提取的活性成分之一,具有抗癌、抗菌、抗炎和抗氧化等功能.研究发现,厚朴酚可通过调控肠道菌群的组成、促进短链脂肪酸和碱性磷酸酶的生成、抑制肠上皮细胞的凋亡、上调肠上皮细胞紧密连接蛋白的表达、调节细胞因子的分泌和增强抗氧化酶的活性等途径,进而维护肠道黏膜屏障的完整性.本文主要就厚朴酚对动物肠道黏膜屏障功能的影响及其调控机制进行综述,为厚朴酚在畜禽生产中的合理应用提供参考.
Abstract
The intestinal mucosa barrier is an important site for interactions between the internal body environ-ment and external environment,which can prevent the invasion of pathogenic microorganisms,toxic and harm-ful substances,and its integrity is critical for animal health.Magnolol is one of the active ingredients extracted from the traditional Chinese medicine Magnolia officinalis,which has the function of anti-cancer,anti-bacteri-al,anti-inflammatory and anti-oxidant.Recent studies have demonstrated that magnolol can maintain the integ-rity of intestinal barrier function via regulating the gut microbiota composition,improving the production of short-chain fatty acids and intestinal alkaline phosphatase,inhibiting the apoptosis of intestinal cells,up-regula-ting tight junction proteins expression in intestinal epithelial cells,modulating cytokine secretion and enhancing the activity of antioxidant enzymes.This article mainly reviewed the effects and regulatory mechanism of mag-nolol on the intestinal mucosal barrier function,to provide a reference for its rational application in livestock and poultry production.[Chinese Journal of Animal Nutrition,2024,36(1):74-85]
基金项目
国家自然科学基金项目(32372928)
国家自然科学基金项目(31902200)
广东省自然科学基金项目(2021A1515012120)
广东省现代农业产业技术体系饲料创新团队项目(2022KJ115)
广东省农业科学院农业优势产业科学团队建设项目(202118TD)
科技创新战略专项资金(高水平农科院建设)(R2023PY-JX015)
科技创新战略专项资金(高水平农科院建设)(R2020YJ-YB2002)
茂名实验室科研启动项目(2021TDQD002)
广东省清远市清城区现代农业产业园项目()
维普
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