Advances in Modification of Saccharomyces cerevisiae and Its Application in Animal Production
Saccharomyces cerevisiae is a frequently utilized yeast in feed production.Improving fermentation efficiency through genetic modification of Saccharomyces cerevisiae is a hot topic in current research.Saccha-romyces cerevisiae and its derivatives could provide high-quality feed protein,improve feed digestibility,sup-press inflammatory response,and maintain intestinal homeostasis,which widely used as feedstuff or feed addi-tives for promoting livestock and poultry breeding health.This review outlines the specific gene editing princi-ples in Saccharomyces cerevisiae and the application of gene editing and synthetic biology in the modification of Saccharomyces cerevisiae.We discuss the progression in the impact of Saccharomyces cerevisiae on improving feed digestibility,modulating immunity and regulating intestinal microbiota.The review further summarizes fields for application and future research of Saccharomyces cerevisiae in animal production.It provides an es-sential theoretical foundation and data support for industrial application of husbandry,and sustainable develop-ment of livestock and poultry for health breeding practices in China.[Chinese Journal of Animal Nutrition,2024,36(3):1473-1483]