Research Progress of Kelech-Like Epichlorohydrin-Associated Protein 1-Nuclear Factor E2-Related Factor 2-Antioxidant Response Element Signaling Pathway and Application of Its Activators in Livestock and Poultry Production
Kelech-like epichlorohydrin-associated protein 1-nuclear factor E2-related factor 2-antioxidant re-sponse element(Keap1-Nrf2-ARE)is a signaling pathway that regulates the expression of various antioxidant enzymes and Ⅱ phase detoxification enzymes in animals,and plays an important role in oxidative stress re-sponse.Studies have found that a variety of probiotics and plant extracts with outstanding antioxidant activity can be used to activate the Keap1-Nrf2-ARE signaling pathway in animals,consequently enhancing the antioxi-dant capacity of the body,alleviating the oxidative stress response of the body,and improving the growth per-formance of livestock and poultry.This review described the basic molecular structure of each part of Keap1-Nrf2-ARE signaling pathway,and the regulatory mechanism of Keap1-Nrf2-ARE signaling pathway in oxida-tive stress response,and also summarized the activators that can activate Keap1-Nrf2-ARE signaling pathway,and the research progress of Keap1-Nrf2-ARE activators applied in livestock and poultry production.Based on our collected findings,we aimed to provide a reference for the development of new feed additives in the field of animal husbandry and further study on alleviating oxidative stress in animals.[Chinese Journal of Animal Nutrition,2024,36(5):2813-2829]
万方数据
维普
