Possible Mechanism of Gut Microbiota Metabolite Trimethylamine Oxide Regulating Liver Lipid Deposition in Dairy Cows
Trimethylamine oxide(TMAO)is a biologically active metabolite of the gut microbiota.Choline,betaine and carnitine in the diet are metabolized by the gut microbiota to produce trimethylamine(TMA),most of which is further oxidized to TMAO by flavin-containing monooxygenase(FMO)in the liver.In recent years,numerous studies have found that plasma TMAO concentration is positively correlated with cardiovascu-lar disease,chronic kidney disease,diabetes,colorectal cancer and non-alcoholic fatty liver disease.The role of TMAO in fat deposition in livestock and poultry has also been confirmed.In this paper,the metabolic process,physiological function and potential role of TMAO in the occurrence and development of fatty liver in dairy cows were reviewed,in order to provide new directions and ideas for the pathogenesis,nutritional regula-tion and prevention of fatty liver in high-yield dairy cows.[Chinese Journal of Animal Nutrition,2024,36(7):4156-4162]
trimethylamine oxidegut microbiotalipid metabolismfatty liver in dairy cows
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维普
