首页|多不饱和脂肪酸对哺乳动物子宫内膜容受性调控作用及机制研究进展

多不饱和脂肪酸对哺乳动物子宫内膜容受性调控作用及机制研究进展

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子宫内膜容受性是影响哺乳动物成功妊娠的关键因素.子宫内膜容受性受多种生物活性因子的调控,探究其调控作用及机制对提高母畜繁殖效率具有重要意义.多不饱和脂肪酸作为调控动物机体脂质代谢的重要生物活性因子,在哺乳动物妊娠前期发挥重要作用,如调节子宫内膜容受性和蜕膜化等.本文从多不饱和脂肪酸调控前列腺素与类固醇激素合成及子宫内膜炎症反应等多方面综述其对子宫内膜容受性的作用,以期为探究多不饱和脂肪酸对哺乳动物子宫内膜容受性的调控机制及其在动物生产中的应用提供参考.
Research Progress on Regulatory Effects and Mechanism of Polyunsaturated Fatty Acids on Mammalian Endometrial Receptivity
Endometrial receptivity is a key factor affecting successful pregnancy in mammals.Endometrial re-ceptivity is regulated by various bioactive factors,and exploring its regulatory role and mechanism is great sig-nificance to improve the reproductive efficiency of female animals.Polyunsaturated fatty acids,as important bioactive molecules that regulate body lipid metabolism,play an important role in the early stages of mammali-an pregnancy,such as regulating endometrial receptivity and decidualization,etc.This article reviews the effects of polyunsaturated fatty acids on endometrial receptivity from various aspects such as regulating prosta-glandin and steroid hormone synthesis and endometrial inflammatory response,with a view to exploring the effects of polyunsaturated fatty acids on endometrial receptivity in mammals,provide reference for the regulato-ry mechanism and its application in animal production.[Chinese Journal of Animal Nutrition,2024,36(7):4222-4232]

endometrial receptivitypolyunsaturated fatty acidsprostaglandinssteroid hormonesinflamma-tory responsemammals

汪小林、秦雪、史新娥、庞卫军

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西北农林科技大学动物科技学院,陕西省动物遗传育种与繁殖重点实验室,杨凌 712100

子宫内膜容受性 多不饱和脂肪酸 前列腺素 类固醇激素 炎症反应 哺乳动物

国家生猪产业技术体系陕西省重点研发计划项目国家重点研发计划课题

CARS-35-PIG2022ZDLNY01-042021YFF1000602

2024

动物营养学报
中国畜牧兽医学会

动物营养学报

CSTPCD北大核心
影响因子:1.297
ISSN:1006-267X
年,卷(期):2024.36(7)