Effects of Alginate Oligosaccharide on Antioxidant Capacity,Immune Function and Intestinal Epithelial Barrier of Low Birth Weight Weaned Piglets
This experiment was conducted to investigate the effects of alginate oligosaccharide(AOS)on the antioxidant capacity,immune function and intestinal epithelial barrier of low birth weight(LBW)weaned pig-lets.One hundred and eight 28-day-old weaned piglets were selected for the experiment,of which 36 piglets with normal birth weight(NBW)were selected as the NBW group,and 72 LBW piglets were randomly divid-ed into LBW group and AOS group.Each group has 6 replicates,with 6 pigs per replicate.Pigs in the NBW and the LBW groups were fed a basal diet,and 500 mg/kg AOS was added to the basal diet fed to the AOS group for 28 days.The results showed as follows:1)the average daily gain and average daily feed intake in the LBW and AOS groups were significantly lower than those of the NBW group(P＜0.05).2)Serum low density lipoprotein cholesterol(LDL-C)content was significantly lower in the AOS group compared with the LBW group(P＜0.05).3)The activities of serum catalase(CAT),superoxide dismutase(SOD),and total antioxidant capacity(T-AOC)were significantly elevated in the AOS group compared with the LBW group(P＜0.05).4)The contents of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the serum of piglets in the LBW group were significantly higher than those in the NBW and AOS groups(P＜0.05);and the content of immunoglobulin M(IgM)in the serum of piglets in the AOS group was significantly higher than that in the LBW and NBW groups(P＜0.05).5)Compared with the LBW group,the villus height and the ra-tio of villus height/crypt depth in the jejunum and ileum of piglets in the AOS group were significantly higher than those in the LBW group(P＜0.05),and the mRNA relative expression levels of tight junction-related genes zonula occluden-1(ZO-1),Claudin-1 and Occludin in the ileal mucosa were significantly increased(P＜0.05).The results indicate that AOS can improve the health of LBW piglets by regulating their antioxidant ca-pacity,immune function and intestinal epithelial barrier integrity.[Chinese Journal of Animal Nutrition,2024,36(7):4271-4280]
万方数据
维普
