This experiment was conducted to investigate the effects of alginate oligosaccharide(AOS)on the antioxidant capacity,immune function and intestinal epithelial barrier of low birth weight(LBW)weaned pig-lets.One hundred and eight 28-day-old weaned piglets were selected for the experiment,of which 36 piglets with normal birth weight(NBW)were selected as the NBW group,and 72 LBW piglets were randomly divid-ed into LBW group and AOS group.Each group has 6 replicates,with 6 pigs per replicate.Pigs in the NBW and the LBW groups were fed a basal diet,and 500 mg/kg AOS was added to the basal diet fed to the AOS group for 28 days.The results showed as follows:1)the average daily gain and average daily feed intake in the LBW and AOS groups were significantly lower than those of the NBW group(P＜0.05).2)Serum low density lipoprotein cholesterol(LDL-C)content was significantly lower in the AOS group compared with the LBW group(P＜0.05).3)The activities of serum catalase(CAT),superoxide dismutase(SOD),and total antioxidant capacity(T-AOC)were significantly elevated in the AOS group compared with the LBW group(P＜0.05).4)The contents of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the serum of piglets in the LBW group were significantly higher than those in the NBW and AOS groups(P＜0.05);and the content of immunoglobulin M(IgM)in the serum of piglets in the AOS group was significantly higher than that in the LBW and NBW groups(P＜0.05).5)Compared with the LBW group,the villus height and the ra-tio of villus height/crypt depth in the jejunum and ileum of piglets in the AOS group were significantly higher than those in the LBW group(P＜0.05),and the mRNA relative expression levels of tight junction-related genes zonula occluden-1(ZO-1),Claudin-1 and Occludin in the ileal mucosa were significantly increased(P＜0.05).The results indicate that AOS can improve the health of LBW piglets by regulating their antioxidant ca-pacity,immune function and intestinal epithelial barrier integrity.[Chinese Journal of Animal Nutrition,2024,36(7):4271-4280]
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