首页|调控脂联素信号通路的天然活性物质研究进展

调控脂联素信号通路的天然活性物质研究进展

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脂联素是由脂肪组织细胞分泌的一种能参与调控糖和脂质代谢、改善胰岛素抵抗、抗炎、抗氧化应激、调控细胞增殖与凋亡以及免疫反应等多种生理或病理过程的蛋白质类激素.本综述概述了脂联素的生物学功能及其发挥生物学效应的关键信号分子,回顾了文献中已证明的能够调节脂联素信号通路的天然活性物质,总结了它们的调控机制和对相关疾病的影响,以期为深入研究应用天然活性物质调控脂联素信号通路,进而为研制预防和治疗犬猫肥胖症、围产期奶牛酮病和脂肪肝、禽脂肪性肝病以及慢性肠道炎症等畜禽代谢紊乱相关疾病,以及促进肠道消化吸收、改善肠道健康、降低体脂含量、改善家畜家禽屠体和肉质性状等方面的天然药物和饲料添加剂提供参考.
Advances in Natural Active Substances Regulating Adiponectin Signaling Pathway
Adiponectin is a protein hormone secreted by adipose tissue cells that can participate in regulating glucose and lipid metabolism,improving insulin resistance,anti-inflammatory,antioxidant stress,regulating cell proliferation and apoptosis,immune response,and other physiological or pathological processes.This arti-cle provided an overview of the biological functions of adiponectin and its key signaling molecules that exert bi-ological effects.It reviewed the natural active substances that have been proven in literature to regulate the adi-ponectin signaling pathway,summarized their regulatory mechanisms,and impacts on related diseases.The aim is to provide references for further research on the application of natural active substances to regulate the adiponectin signaling pathway,and to develop natural drugs and feed additives for the prevention and treatment of disease associated with metabolic disorders in livestock and poultry such as obesity in dogs and cats,ketosis and fatty liver in perinatal cows,fatty liver disease in poultry,chronic intestinal inflammation,as well as pro-moting intestinal digestion and absorption,improving intestinal health,reducing body fat content,and impro-ving the carcass and meat quality of livestock and poultry.[Chinese Journal of Animal Nutrition,2024,36(8):4881-4895]

adiponectinsignaling pathwayregulationnatural active substancesmetabolic disease of live-stock and poultry

郑雯、吕永乐、栾新红、曹中赞

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沈阳农业大学动物科学与医学学院,沈阳 110161

脂联素 信号通路 调控 天然活性物质 畜禽代谢性疾病

2024

动物营养学报
中国畜牧兽医学会

动物营养学报

CSTPCD北大核心
影响因子:1.297
ISSN:1006-267X
年,卷(期):2024.36(8)