Effects of Baicalein Solid Dispersion on Growth Performance,Antioxidant Capacity and Intestinal Flora of Calves
This experiment was conducted to investigate the effects of baicalein solid dispersion on growth per-formance,antioxidant capacity and intestinal flora of calves.Thirty-six healthy(7±5)days of age Holstein calves with body weight of(45.82±3.37)kg were randomly divided into 3 groups with 12 replicates per group and 1 calf per replicate.Calves in the control group(CON group)were fed a basal diet,and others in baica-lein group(BAI group)and solid dispersion group(SD group)were fed the basal diet supplemented with 0.4％baicalein and baicalein solid dispersion containing 0.4％baicalin,respectively.The experiment lasted for 30 days.The results showed as follows:1)compared with CON group,the body weight on day 30 of BAI group and SD group was significantly increased(P＜0.05),and the average daily gain(ADG)of SD group was significantly increased(P＜0.05).Compared with BAI group,the body weight on day 30 and ADG of SD group were significantly increased(P＜0.05).2)Compared with CON group,the serum glutathione peroxi-dase(GSH-Px),superoxide dismutase(SOD)activities and total antioxidant capacity(T-AOC)of BAI group and SD group were significantly increased(P＜0.05),and the serum malondialdehyde(MDA)content was significantly decreased(P＜0.05).Compared with BAI group,the serum GSH-Px,SOD activities and T-AOC of SD group were significantly increased(P＜0.05),and the serum MDA content was significantly de-creased(P＜0.05).3)Compared with CON group,the intestinal flora Chaol index and Shannon index of BAI group and SD group were significantly increased(P＜0.05).Compared with BAI group,the intestinal flora Chaol index and Shannon index of SD group were significantly increased(P＜0.05).At the phylum level,compared with CON group,the relative abundance of Firmicutes in intestine of BAI group and SD group was significantly increased(P＜0.05),and the relative abundances of Bacteroidetes,Proteobacteria and Fusobacte-ria in intestine were significantly decreased(P＜0.05).Compared with BAI group,the relative abundance of Firmicutes in intestine of SD group was significantly increased(P＜0.05).At the genus level,compared with CON group,the relative abundance of Bacteroides in intestine of SD group was significantly decreased(P＜0.05),and the relative abundances of Faecalibacterium and Subdoligranulum in intestine of BAI group and SD group were significantly increased(P＜0.05).In conclusion,adding baicalein solid dispersion in basal diet can improve the growth performance and antioxidant capacity of calves,increase the relative abundance of benefi-cial bacteria and reduce the relative abundance of harmful bacteria,and thus improve the intestinal flora struc-ture.[Chinese Journal of Animal Nutrition,2024,36(8):5130-5140]
万方数据
维普
