Effects of Dietary Sodium Butyrate on Growth Performance,Serum Biochemical and Antioxidant Indices and Intestinal Health of Juvenile Channel Catfish(Ictalurus punctatus)
This study was conducted to investigate the effects of dietary sodium butyrate on growth perform-ance,serum biochemical and antioxidant indices and intestinal health of juvenile channel catfish(Ictalurus punctatus).A total of 480 healthy juvenile channel catfish with an initial body weight of(4.37±0.03)g were randomly divided into 4 groups with 3 replicates per group and 40 fish per replicate.Fish in the control group were fed a basal diet(without sodium butyrate supplementation),and the others in the experimental groups were fed the basal diets supplemented with 0.06％,0.12％and 0.18％sodium butyrate,respectively.The trial lasted for 8 weeks.The results showed as follows:1)compared with the control group,the feed conversion ra-tio in 0.12％sodium butyrate supplemental group was significantly decreased(P＜0.05),the weight gain rate had a tendency to be increased(P＞0.05),the protein and lipid deposition rates were significantly increased(P＜0.05),and the intestinal protease and amylase activities were significantly increased(P＜0.05).2)Com-pared with the control group,the activities of serum superoxide dismutase(SOD)and catalase(CAT)in ex-perimental groups were significantly increased(P＜0.05);the serum glutathione peroxidase(GSH-Px)activity in 0.12％sodium butyrate supplemental group was significantly increased(P＜0.05),and the serum malondial-dehyde(MDA)content was significantly decreased(P＜0.05);the serum total cholesterol(TCHO)content in 0.12％and 0.18％sodium butyrate supplemental groups was significantly decreased(P＜0.05).3)Com-pared with the control group,the villus width of foregut in 0.06％and 0.12％sodium butyrate supplemental groups was significantly increased(P＜0.05),and the villus height,muscular thickness and wall thickness of foregut in 0.12％and 0.18％sodium butyrate supplemental groups were significantly increased(P＜0.05);the muscular thickness and wall thickness of hindgut in experimental groups were significantly increased(P＜0.05).4)Compared with the control group,the Ace index and Chaol index of intestinal microbiota in 0.12％and 0.18％sodium butyrate supplemental groups were significantly increased(P＜0.05).At the phylum level,compared with the control group,the Proteobacteria relative abundance in 0.12％and 0.18％sodium butyrate supplemental groups was significantly decreased(P＜0.05),the Spirochaetota relative abundance in 0.12％so-dium butyrate supplemental group was significantly increased(P＜0.05),and the Fusobacteriota relative abun-dance in 0.18％sodium butyrate supplemental group was significantly increased(P＜0.05).In conclusion,di-etary sodium butyrate can improve the diet utilization rate,enhance antioxidant capacity,improve intestinal tis-sue morphology,and positively regulate the intestinal microbiota composition of juvenile channel catfish(Icta-lurus punctatus),and the optimum supplemental level is 0.12％.[Chinese Journal of Animal Nutrition,2024,36(9):5895-5909]
channel catfishsodium butyrategrowth performanceserum biochemical indicesantioxidantintestinal health
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