基于数据挖掘探讨中药防治黄曲霉菌感染的用药规律

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中文摘要：本研究基于网络药理学等数据挖掘方法探究中药干预黄曲霉菌感染的用药规律.通过 GeneCards数据库获得并筛选黄曲霉菌感染潜在靶点,同时在中药系统药理学数据库与分析平台(TCMSP)筛选口服生物利用度≥30％、类药性≥0.18的候选化合物及中药,随后构建关键靶点-候选化合物-候选中药网络,并通过检索各候选中药的性、味、归经等相关信息,分析出相关用药规律.结果表明:利用数据库共筛选出69个黄曲霉菌感染相关靶点,收集到54个候选化合物,筛选到275味中药.用药频次统计结果显示,防治黄曲霉菌感染的候选中药中,苦味、寒性居多,主要归肝、肺二经.本文系统地分析了中药干预黄曲霉菌感染的小分子物质基础,归纳了一般用药规律,可为临床治疗黄曲霉菌感染等相关疾病的新药研发及中药治疗提供一定的参考及思路.

外文标题：Medication Rule of Chinese Herbs in Preventing and Treating Aspergillus flavus Infection Based on Data Mining

外文摘要：This study was based on data mining methods such as network pharmacology to explore the medica-tion rule of intervention of Chinese herbs in Aspergillus flavus infection.Potential targets of Aspergillus flavus infection were obtained through GeneCards database.At the same time,candidate compounds and Chinese herbs with oral bioavailability≥30％and drug class ≥0.18 were screened on the TCM System Pharmacology Technology Platform(TCMSP),and then the target-compound-TCM network was constructed,and the rele-vant medication rule were analyzed by retrieving the property,taste,meridial distribution and other relevant in-formation of each candidate Chinese herbs.The results showed that a total of 69 targets related to Aspergillus flavus infection were screened,54 candidate compounds and 275 Chinese herbs were collected.The statistics results of frequency showed that the main taste of candidate Chinese herbs that could interfere with Aspergillus flavus infection was bitter,and the drug was mostly cold,mainly attributed to liver and lung channels.This ar-ticle systematically discussed the small molecule substance basis of Chinese herbs intervention in Aspergillus fla-vus infection,summarized the general medication rule of Chinese herbs,and provided ideas for the clinical treatment of Aspergillus flavus infection and other related diseases of new drug development and Chinese herb treatment.[Chinese Journal of Animal Nutrition,2024,36(9):6095-6108]

外文关键词：

Aspergillus flavusChinese herbsmedication ruledata mining

作者：

董雯雯、张玉霞、孟凯、李峰、张世栋、宋华鲁、王云超、刘庆彬、朱应波、李桂明、袁小远

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作者单位：

山东省农业科学院家禽研究所,济南 250100

济南市农业实验动物与比较医学重点实验室,济南 250023

山东省农业科学院农业信息与经济研究所,济南 250100

山东蓝海生态农业有限公司,东营 257100

东营蓝海生态养殖有限公司,东营 257100

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关键词：

黄曲霉菌中药用药规律数据挖掘

基金：

山东省自然科学基金项目山东省农业科学院农业科技创新工程山东省农业科学院农业科技创新工程山东省农业科学院农业科技创新工程山东省农业科学院农业科技创新工程山东省农业科学院农业科技创新工程山东省重点研发计划项目泰山产业领军人才工程专项山东省农业良种工程课题任务书

项目编号：

ZR2021MC060CXGC2024D11CXGC2024B07CXGC2024A08CXGC2023A10CXGC2023A222022LZGC014tscx2023060462022LZGC013

出版年：

2024

DOI：

10.12418/CJAN2024.517

动物营养学报

中国畜牧兽医学会

动物营养学报

CSTPCD北大核心

影响因子：1.297

ISSN：1006-267X

年,卷(期)：2024.36(9)