This study was based on data mining methods such as network pharmacology to explore the medica-tion rule of intervention of Chinese herbs in Aspergillus flavus infection.Potential targets of Aspergillus flavus infection were obtained through GeneCards database.At the same time,candidate compounds and Chinese herbs with oral bioavailability≥30％and drug class ≥0.18 were screened on the TCM System Pharmacology Technology Platform(TCMSP),and then the target-compound-TCM network was constructed,and the rele-vant medication rule were analyzed by retrieving the property,taste,meridial distribution and other relevant in-formation of each candidate Chinese herbs.The results showed that a total of 69 targets related to Aspergillus flavus infection were screened,54 candidate compounds and 275 Chinese herbs were collected.The statistics results of frequency showed that the main taste of candidate Chinese herbs that could interfere with Aspergillus flavus infection was bitter,and the drug was mostly cold,mainly attributed to liver and lung channels.This ar-ticle systematically discussed the small molecule substance basis of Chinese herbs intervention in Aspergillus fla-vus infection,summarized the general medication rule of Chinese herbs,and provided ideas for the clinical treatment of Aspergillus flavus infection and other related diseases of new drug development and Chinese herb treatment.[Chinese Journal of Animal Nutrition,2024,36(9):6095-6108]
维普
万方数据