Factors Affecting Autophagy Occurring in Intestinal Epithelial Cells of Piglets and Their Nutritional Regulation
With the ban of using in-feed antibiotics,the challenges such as intestinal barrier damage,oxidative stress and intestinal diseases have become more serious.Research on nutritional regulation to improve piglet in-testinal health has received intense interests for the academic community and the swine industry.In recent years,intestinal epithelial cell autophagy has been demonstrated to play crucial roles in reducing intestinal oxi-dative damage,protecting the intestinal barrier,and maintaining intestinal homeostasis in piglets.Therefore,this paper comprehensively reviews the process of cell autophagy,factors affecting intestinal epithelial cell auto-phagy in piglets,and the progress in nutritional regulation applications,in order to provide scientific reference for the rational development and application of nutritional regulation techniques based on intestinal epithelial cell autophagy as potential targets to improve piglet intestinal health and homeostasis.[Chinese Journal of Animal Nutrition,2024,36(11):6826-6840]