摘要
随着饲料端全面禁抗后,仔猪所面临的肠道屏障损伤、氧化应激与肠道疾病等问题变得更加严峻.改善仔猪肠道健康的营养调控研究成为学术界和养猪行业共同关注的焦点.近年研究表明,肠道上皮细胞自噬在减少仔猪肠道氧化损伤、保护肠道屏障和维持肠道稳态等过程发挥重要作用.因此,本文主要综述了细胞自噬发生过程、仔猪肠道上皮细胞自噬发生的影响因素及其营养调控的相关应用进展,以期为基于肠道上皮细胞自噬作为调控靶点,改善仔猪肠道健康和稳态的营养调控技术开发和应用提供参考.
Abstract
With the ban of using in-feed antibiotics,the challenges such as intestinal barrier damage,oxidative stress and intestinal diseases have become more serious.Research on nutritional regulation to improve piglet in-testinal health has received intense interests for the academic community and the swine industry.In recent years,intestinal epithelial cell autophagy has been demonstrated to play crucial roles in reducing intestinal oxi-dative damage,protecting the intestinal barrier,and maintaining intestinal homeostasis in piglets.Therefore,this paper comprehensively reviews the process of cell autophagy,factors affecting intestinal epithelial cell auto-phagy in piglets,and the progress in nutritional regulation applications,in order to provide scientific reference for the rational development and application of nutritional regulation techniques based on intestinal epithelial cell autophagy as potential targets to improve piglet intestinal health and homeostasis.[Chinese Journal of Animal Nutrition,2024,36(11):6826-6840]
维普
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