Effects of Canine-Derived Lactobacillus acidophilus GLA09 on Intestinal Flora and Metabolome of Adult Beagles
This study aimed to investigate the effects of canine-derived Lactobacillus acidophilus GLA09 on in-testinal flora and metabolome of adult beagles.Twelve adult beagles with body weight of(17.93±2.03)kg were randomly divided into 2 groups with 6 dogs per group.The control group(CK group)was fed a basal di-et,and the probiotic group(LA group)was fed a basal diet+2x1010 CFU/d.The pre-experimental period las-ted for 7 days,and the experimental period lasted for 28 days.The results showed as follows:1)there were no significant differences in the observed species and Chaol,PD whole tree,Shannon and Simpson indices in in-testinal flora between CK group and LA group(P＞0.05).2)Compared with CK group,the relative abun-dances of Lactobacillus and Parasutterella in intestine of LA group were significantly increased(P＜0.05).3)Compared with CK group,there were 21 down-regulated differential metabolites and 40 up-regulated differenti-al metabolites of LA group.4)Compared with CK group,the differential metabolites of LA group were anno-tated to the metabolic pathways of aminoglycans and nucleotide sugars,ABC transporter proteins and pyrimi-dine metabolism.In summary,dietary canine-derived Lactobacillus acidophilus GLA09 can increase the rela-tive abundances of Lactobacillus and Bifidobacterium in intestine of beagles,and up-regulate the functional me-tabolites such as N-acetylglucosamine,L-arabinose,and glutamate,resulting in an improvement in canine in-testinal health.[Chinese Journal of Animal Nutrition,2024,36(11):7294-7304]
万方数据
维普
