Chirality research holds paramount theoretical significance and practical prospects in the field of organic chemistry.With the advancement of science and technology and the deepening of our understanding,a plethora of new concepts and techniques continue to emerge.Inherent chirality arises from the introduction of a curvature in an ideal planar structure that is devoid of perpendicular symmetry planes in its bidimensional representation,distinguished from conventional central,axial,planar,and helical chirality.It possesses unique stereochemistry and offers extensive application prospects.This review focuses on the structural characteristics,synthesis,and separation of naturally occurring inherent chiral compounds,synthetically derived chiral calixarenes,pillararenes,cyclotriveratrylenes,tribenzotriquinacenes,saddle-shaped octatomic rings,sumanenes,and cage compounds.Furthermore,it sheds light on future developmental directions and new opportunities in this domain.
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