Photoredox/Nickel-Catalyzed Synthesis of 4'-Methoxypropiophenone
The photo-nickel synergistic catalytic reaction emerges as a promising synthetic method,offering advantages such as high yields,mild reaction conditions,and broad scope.Guided by the principles of sustainable development,we have successfully synthesized valued aromatic ketone derivatives utilizing prevalent industrial feedstocks,aromatic carboxylic acids and ethylene under mild reaction conditions.It would be the first example of photo-nickel synergistic catalyzed reaction between aromatic acids and ethylene under air atmosphere.This synthetic method features in a high efficiency utilization of resource,simple operation and easy access for the students to grasp.This approach not only bridges a knowledge gap in teaching photochemical reactions within foundational organic chemistry experiments but also holds substantial practical and pedagogical merit.
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维普
