Amides are one of the most important classes of compounds that widely exist in bioactive molecules such as peptides and alkaloids. They also have important applications in various fields such as chemical engineering, dyes and pharmaceutical development. Therefore, studying the synthesis and structural identification of amide compounds is of great significance. Due to the delocalization of lone pair electrons from the nitrogen atom of amide compounds to the carbonyl group (C=O), the C―N bond in the amide RCO―N exhibits partial double bond properties, preventing free rotation and resulting in complex nuclear magnetic resonance hydrogen spectrum (1H NMR). This article summarizes the characteristics of 1H NMR spectra of amides and discusses some factors influencing amide isomerization. This article will cultivate students' ability to analyze the 1H NMR of amides and deepen their understanding and knowledge of amide compounds.
Amide compoundsNuclear magnetic resonance hydrogen spectroscopyIsomerization
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