Efficient Rapid Synthesis and Antibacterial Activities of Tosylhydrazones: A Recommended Innovative Chemistry Experiment for Undergraduate Medical University
Efficient Rapid Synthesis and Antibacterial Activities of Tosylhydrazones: A Recommended Innovative Chemistry Experiment for Undergraduate Medical University
In the teaching process of the organic chemistry experiment, the content typically involves the synthesis or extraction of a certain compound, often lacking in structural identification and property testing of the target compound. To improve the quality of organic chemistry experimental teaching, and cultivate students' scientific research literacy and innovation ability, commercially available aldehydes, ketones and p-toluenesulfonyl hydrazide are used as reactants. N-tosylhydrazone derivatives were effectively synthesized within 1 min under solvent-free conditions by using a grinding method at room temperature, and the structure and properties of the products were also studied. Compounds 3i and 3h have the best inhibitory effect against Escherichia coli during antibacterial experimental research. The experiment, encompassing synthesis, TLC detection, and column chromatography operations, serves to hone students' operational skills in organic compound synthesis, purification, and structural identification. Students are required to consult literature independently and proficiently utilize software tools like Origin, ChemDraw and MestRec, which fosters their ability to analyze and resolve problems. This improved experimental framework, aimed at elevating students' comprehensive qualities, is well-suited for the foundational organic chemistry experimental teaching.
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