协同芳香亲核取代反应
Concerted Nucleophilic Aromatic Substitution Reactions
林文涛 1王文峰 1袁耀锋 1徐春发1
作者信息
摘要
芳香亲核取代反应被有机化学家广泛地用于有机化合物的合成,是最重要的合成反应之一.教材中对于该反应机理的介绍为分步过程,但是随着研究的深入,通过协同过程的芳香亲核取代反应已经被广泛证实.本文简要回顾了分步进行的芳香亲核取代反应,重点介绍了协同芳香亲核取代反应的几个实例,阐述了反应设计对机理研究的重要性.通过将科研成果融入教学过程,有助于进一步加深对芳香亲核取代反应的理解.
Abstract
Nucleophilic aromatic substitution reactions play a crucial role in the synthesis of organic compounds and are considered to be one of the most important synthetic transformations. Traditionally,these reactions have been described as stepwise processes in textbooks. However,with further research,the existence of concerted nucleophilic aromatic substitution reactions has been widely confirmed. This paper provides a brief overview of the stepwise pathway of nucleophilic aromatic substitution reactions and focuses on several examples of concerted reactions,highlighting the importance of reaction design in mechanistic studies. Integrating cutting-edge research findings into teaching can enhance students' understanding of nucleophilic aromatic substitution reactions.
关键词
芳香亲核取代反应/协同/分步/反应机理Key words
Nucleophilic aromatic substitution reaction/Concerted/Stepwise/Reaction mechanism引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据