一锅多组分反应选择性合成二芳基甲胺和三芳基甲烷——推荐一个有机化学综合实验
Selective Synthesis of Diarylmethyl Anilines and Triarylmethanes via Multicomponent Reactions:Introduce a Comprehensive Experiment of Organic Chemistry
王一诺 1王思然 1赵奕龙 1徐大振1
作者信息
- 1. 南开大学化学学院,农药国家工程研究中心,天津 300071
- 折叠
摘要
本文介绍了一个有机化学综合实验,实验以水杨醛、苯硼酸和芳胺为反应底物,通过芳胺上取代基控制亲核性选择性地制备二芳基甲胺和三芳基甲烷,并利用核磁共振氢谱(1H NMR)和碳谱(13C NMR)对产物结构进行表征.本实验与理论知识相结合,启发学生进行机理方面的思考,帮助他们开拓知识视野,更好地树立"绿色化学"理念和环保意识.
Abstract
This article presents a comprehensive organic chemistry experiment in which salicylaldehyde,phenylboronic acid,and aromatic amines are employed as the substrates.The selective synthesis of diarylmethyl aniline and triarylmethane could be achieved through the control of substituents.The structure of the product is characterized by 1H NMR and 13C NMR.This experiment combines theoretical knowledge to inspire students to think about mechanisms,helps them broaden their knowledge horizons,and establishes the concept of "green chemistry" and environmental awareness.
关键词
多组分反应/苯胺/苯硼酸/绿色化学Key words
Multicomponent reactions/Aniline/Phenylboronic acid/Green chemistry引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据