Experimental Design for the Two-Step Synthesis of Paracetamol from 4-Hydroxyacetophenone
A two-step synthetic experiment to produce paracetamol from 4-hydroxyacetophenone was designed for undergraduate organic chemistry courses.The experiment begins with the condensation of 4-hydroxyacetophenone with hydroxylamine to form 4-hydroxyacetophenone oxime.This oxime then undergoes a Beckmann rearrangement catalyzed by cyanuric chloride to yield paracetamol.The experiment incorporates several essential organic laboratory techniques,such as reflux,extraction,drying,filtration,rotary evaporation,thin-layer chromatography,and column chromatography,providing students with comprehensive training in organic synthesis.By synthesizing a compound of significant medical and economic value,the experiment demonstrates practical applications of organic synthesis,thereby enhancing student interest in organic chemistry.Additionally,the use of a small molecule organic catalyst for the Beckmann rearrangement deepens students'understanding of the principles of organic catalysis and the mechanism of the Beckmann rearrangement.
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