Viruses have long been a significant threat to human survival and development,with recent events such as the COVID-19 pandemic vividly highlighting their dangers.Small molecule drugs have historically played a crucial role in humanity's efforts to combat diseases.In the fight against viruses,humans have developed a range of strategies,with small molecule antiviral drugs occupying a pivotal position.Drawing inspiration from the classic"Thirty-Six Stratagems"of ancient Chinese military tactics,this article provides a concise overview of the developmental history of small molecule antiviral drugs,focusing on the design principles and mechanisms of representative drugs like idoxuridine,saquinavir,and oseltamivir.Furthermore,the article provides insights into future directions for small molecule antiviral drugs and antiviral methodologies.
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