The Friedel-Crafts alkylation reaction represents a pivotal organic transformation for the formation of carbon-carbon bonds,holding extensive applications within the realms of both organic synthesis and pharmaceutical chemistry.This article presents a comprehensive review of the mechanism underlying the Friedel-Crafts alkylation reaction,alongside recent advancements in various catalytic approaches,such as metal catalysis,organocatalysis,visible light photocatalysis,enzymatic and electrochemical catalysis.By merging cutting-edge scientific developments with undergraduate teaching content,this review endeavors to inspire students'learning interests while fostering their capacity for innovative thinking.
维普
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