The substitution of heteroaromatics by nucleophilic carbon-centered radicals is known as the Minisci reaction.In this study,efficient synthesis of 4-(benzo[d]thiazol-2-yl)butan-2-one was achieved through radical alkylation between 1-methylcyclopropan-1-ol and benzo[d]thiazole under silver-catalyzed and aqueous conditions.This method offers advantages such as simple operation procedures,mild reaction conditions,and excellent atom-economy.Undergraduates have successfully validated this reaction,making it a suitable candidate for a teaching experiment that effectively supplements knowledge in radical chemistry.
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