摘要
新工科背景下,化学类专业课程不仅强调培养学生扎实的化学基本功,而且注重多学科交叉融合,培养学生与时俱进、勇于创新的科学精神."苯佐卡因的制备"是一个经典的有机化学综合性本科教学实验.在原先的反应过程中,酯化反应产生大量废酸,还原反应步骤繁琐,总体反应时间长,缺少趣味性.为了提升该实验的有效时长,加强实验过程的绿色环保性,提升实验的拓展性与探究性,我们通过引入前沿科学成果对该制备反应进行了改进.改进后的实验,在酯化反应步骤使用低共熔溶剂进行催化,可循环使用,绿色环保.在还原反应步骤,则是使用连二硼酸作为还原剂、4,4'-联吡啶作为催化剂,在室温下即可反应,反应温和,颜色变化明显,富有趣味性.该改进实验,不仅可以激发学生的学习兴趣,而且可以提高学生的科研素养,培养学生的绿色化学理念,以及独立思考和分析解决问题的能力.
Abstract
In the context of emerging engineering education,chemistry courses emphasize not only the development of students'solid foundational skills in chemistry but also the integration of multidisciplinary knowledge to foster an innovative scientific spirit."The Preparation of Benzocaine"is a classic undergraduate experiment in comprehensive organic chemistry.However,the original reaction procedure involves the generation of substantial waste acid during esterification,a cumbersome and time-consuming reduction step,and lacks engagement.To enhance efficiency,environmental friendliness,expansiveness and exploratory nature of the experiment,cutting-edge scientific advancements have been integrated into the preparation reaction.In the improved experiment,a deep eutectic solvent is utilized as a catalyst in the esterification reaction,which is recyclable and environmentally friendly.For the reduction step,tetrahydroxydiboron serves as the reducing agent and 4,4'-bipyridine as the catalyst,enabling the reaction to take place at room temperature with a noticeable color change,thereby making it engaging.This improved experiment not only stimulates students'interest in learning,but also improves students'scientific research literacy,and cultivates students'green chemistry concept,independent thinking,and problem-solving skills.
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