Preparation and Performance Characterization of the Second Near-Infrared Phototheranostic Probe:A New Design and Teaching Practice of Polymer Chemistry Comprehensive Experiment
Cancer has become one of the most significant threats to humans,and the development of novel phototherapeutic agents for precise diagnosis and efficient treatment of cancer is crucial.This article introduces a new design and teaching practice of a polymer chemistry comprehensive experiment,which involves the preparation process and related performance testing of a novel conjugated polymer based second near-infrared phototheranostic probe.This experiment includes the synthesis of conjugated polymers,preparation of water-soluble nanoparticles,determination of absorption and emission spectra,analysis of photothermal and photodynamic properties as well as second near-infrared fluorescence imaging,and study of the phototoxicity to cancer cells.This experiment has strong scientific and cutting-edge content,which can improve students'experimental operation skills,guide them to apply their learned knowledge for independent thinking,and inspire students'innovation and scientific research thinking.
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