癫痫杂志2024,Vol.10Issue(3) :249-253.DOI:10.7507/2096-0247.202401010

局灶性皮层刺激术在耐药性局灶性癫痫的应用进展

The application progress of focal cortical stimulation in drug-resistant focal epilepsy

向淇 赵薇 刘静 姜荆 严翠华 刘安如 韩涛 刘学伍
癫痫杂志2024,Vol.10Issue(3) :249-253.DOI:10.7507/2096-0247.202401010

局灶性皮层刺激术在耐药性局灶性癫痫的应用进展

The application progress of focal cortical stimulation in drug-resistant focal epilepsy

向淇 1赵薇 2刘静 3姜荆 1严翠华 1刘安如 1韩涛 4刘学伍1
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作者信息

  • 1. 山东大学齐鲁医学院(济南 250012);山东省立医院神经内科(济南 250021)
  • 2. 山东大学齐鲁医学院(济南 250012)
  • 3. 山东省立第三医院高压氧科(济南 250031)
  • 4. 山东省立医院神经内科(济南 250021)
  • 折叠

摘要

全球约有5 000万癫痫患者,中国约有900万.大约1/3的癫痫患者对传统抗癫痫发作药物(Antiseizure medications,ASMs)的耐药性,局灶性皮层刺激术(Focal cortical stimulation,FCS)作为一种基于神经刺激的新型神经调控疗法,显现出治疗耐药性局灶性癫痫的潜力.FCS通过降低皮层区域的异常兴奋性来减少发作频率,与传统手术相比,具有更低的风险,尤其适合手术难以定位致痫灶的患者.其可调节性为医生提供了治疗灵活性,能够根据患者状况调整治疗方案.最新研究展示了 FCS在实际临床中的应用效果,突出了其在降低耐药性癫痫发作频率方面的优势.文章最后探讨了 FCS的未来应用前景,强调了长期疗效评估和患者适应性方面的研究需求,展现了其在癫痫治疗领域的重要潜力和发展方向.

Abstract

Approximately 70 million people worldwide suffer from epilepsy,with about 9 million in China.About one-third of patients demonstrating resistance to traditional antiseizure medications(ASMs),Focal Cortical Stimulation(FCS)emerges as a novel neuromodulation therapy based on neural stimulation,showing potential in treating drug-resistant focal epilepsy.FCS reduces seizure frequency by diminishing abnormal excitability in cortical areas.Compared to traditional surgery,it carries lower risks and is particularly suited for patients whose epileptogenic foci are difficult to surgically localize.Its adjustability provides physicians with treatment flexibility,allowing them to tailor therapy based on patient conditions.Recent studies highlight the practical clinical application of FCS,underscoring its advantages in reducing the frequency of drug-resistant epilepsy seizures.The article concludes by exploring the future prospects of FCS,emphasizing the need for research in long-term efficacy assessment and patient adaptability,thus demonstrating its significant potential and direction for development in the field of epilepsy treatment.

关键词

癫痫/耐药性癫痫/局灶性皮层刺激术/神经调控技术/临床试验

Key words

Epilepsy/Drug-resistant epilepsy/Focal Cortical Stimulation/Neuromodulation technology/Clinical trials

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出版年

2024
癫痫杂志

癫痫杂志

ISSN:
参考文献量21
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