癫痫杂志2024,Vol.10Issue(3) :260-264.DOI:10.7507/2096-0247.202402001

血清同型半胱氨酸水平与癫痫关系的研究进展

The relationship between serum homocysteine and post-stroke epolepsy

周晓敏 张忠胜
癫痫杂志2024,Vol.10Issue(3) :260-264.DOI:10.7507/2096-0247.202402001

血清同型半胱氨酸水平与癫痫关系的研究进展

The relationship between serum homocysteine and post-stroke epolepsy

周晓敏 1张忠胜1
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作者信息

  • 1. 广州医科大学附属清远医院神经内科(清远 511500)
  • 折叠

摘要

同型半胱氨酸(Homocysteine,Hcy)是蛋氨酸和半胱氨酸代谢过程中的重要中间产物,其在甲基化过程中起着关键作用.癫痫是神经系统常见的疾病之一,长期反复的癫痫发作不仅会对脑组织造成损害,也会引起认知障碍.现有医疗手段主要集中于缓解控制病情,对于癫痫根本性的病因学仍有待提高,探索癫痫发作的病因,从根本上防治癫痫发作,仍是我们的长期奋斗的方向.高同型半胱氨酸血症(Hyperhomocysteinemia,HHcy)与众多疾病有关,流行病学研究表明,10%~40%的癫痫患者血清中的Hcy含量高于正常人群,因此探究血清Hcy与癫痫之间的关系,能为临床癫痫的诊断和治疗提供帮助.

Abstract

Homocysteine is an intermediate product of methionine and cysteine metabolism,and plays a key role in methylation.Epilepsy is one of the common diseases of the nervous system,long-term repeated seizures will not only cause damage to the brain tissue,but also cause cognitive impairment.At present,the clinical treatment for epilepsy is still mainly to control symptoms,the fundamental etiology of epilepsy still needs to be improved,to explore the etiology of seizures,fundamentally control seizures,is still our long-term struggle direction.High homocysteine is associated with many diseases.Epidemiological studies have shown that the serum homocysteine level of 10%~40%of epilepsy patients is higher than that of the normal population.By exploring the relationship between serum Hcy and epilepsy,We expect to provide help for the diagnosis and treatment of clinical epilepsy.

关键词

癫痫/同型半胱氨酸/卒中后癫痫/抗癫痫发作药物/共患病

Key words

Epilepsy/Homocysteine/Poststroke seizures/Antiseizure medications/Comorbidity

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出版年

2024
癫痫杂志

癫痫杂志

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参考文献量45
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