miRNA对癫痫诊断价值的系统评价与Meta分析
MicroRNA as diagnostic markers of epilepsy:systematic review and meta-analysis
李安 1陈睿 1薛国芳2
作者信息
- 1. 山西医科大学第二临床医学院(太原 030001)
- 2. 山西医科大学第二医院神经内科(太原 030001)
- 折叠
摘要
目的 系统评价和Meta分析miRNA作为癫痫患者诊断工具的准确性.方法 系统检索PubMed、EMBASE、The Cochrane Library和Web of Science数据库,搜集有关miRNA诊断癫痫的文献,时间截止至2024年1月1日.由两名研究人员独立筛选、提取文献,并以协商的方式解决差异.采用QUADAS-2评价工具对纳入的研究进行质量评估.采用Review Manager 5.4、Meta-Disc 1.4及Stata17.0软件进行统计分析.结果 共纳入17篇文献,包括942例癫痫患者和932例健康对照者.miRNA在癫痫诊断中合并敏感度为0.76[95％CI(0.71,0.79)],合并特异度为 0.78[95％CI(0.74,0.82)],SROC 曲线下面积为 0.84[95％CI(0.80,0.87)].亚组分析表明miRNA对颞叶癫痫,特别是伴有海马硬化的内侧颞叶癫痫(Mesial temporal lobe epilepsy with hippocampal sclerosis,MTLE-HS)有更高诊断价值.结论 研究表明miRNA可能是癫痫,尤其是颞叶癫痫诊断的一种有前途的工具,但仍需更多高质量的研究予以支持.
Abstract
Objective The aim of this meta-analysis and systematic review is to assess the effectiveness of microRNAs as a diagnostic tool for individuals with epilepsy.Methods A systematic search of PubMed,EMBASE,the Cochrane Library,and Web of Science databases was performed to collect literature on miRNA diagnosis of epilepsy up to January 1,2024.Two researchers independently screened and extracted the literature and resolved discrepancies by negotiation.The QUADAS-2 evaluation tool was used to assess the quality of the included studies.Statistical analysis was performed using Review Manager 5.4,Meta-Disc 1.4,and Stata 17.0.Results A total of 17 papers were included,including 942 patients with epilepsy and 932 healthy controls.miRNA in the diagnosis of epilepsy had a combined sensitivity of 0.76[95％CI(0.71,0.79)],combined specificity of 0.78[95％CI(0.74,0.82)],and area under the SROC curve of 0.84[95％CI(0.80,0.87)].Subgroup analysis showed that miRNA had higher diagnostic value for temporal lobe epilepsy,especially medial temporal lobe epilepsy with hippocampal sclerosis(MTLE-HS).Conclusion The study suggests that miRNA may be a promising tool for the diagnosis of epilepsy,especially temporal lobe epilepsy,but more high-quality studies are needed to support it.
关键词
生物标志物/诊断/癫痫/Meta分析/miRNAKey words
Biomarkers/Diagnosis/Epilepsy/Meta-analysis/miRNA引用本文复制引用
基金项目
山西省自然科学基金(202303021211213)
中国抗癫痫协会癫痫科研基金(UCB2017007)
山西人力资源和社会保障厅(晋财社[2019]91号)
出版年
2024
NETL
NSTL
万方数据