婴儿癫痫性痉挛综合征治疗现状
Current status of treatment for infantile epileptic spasm syndrome
赵考明 1易招师 1钟建民1
作者信息
- 1. 江西省儿童医院神经内科(南昌 330006)
- 折叠
摘要
婴儿癫痫性痉挛综合征(Infantile epileptic spasm syndrome,IESS)是一种年龄依赖性癫痫性脑病,多于3～12个月内起病,常用抗癫痫发作药物(Anti-seizure medications,ASMs)疗效不佳,远期控制率低,复发率高,常遗留有发育落后/智力障碍、孤独症谱系障碍等后遗症.目前IESS的一线推荐治疗为促肾上腺皮质激素(Adrenocorticotropic hormone,ACTH)、肾上腺皮质激素和氨己烯酸,无效者可试用其他ASMs、生酮饮食和手术治疗等.本文将对IESS治疗现状及相关临床应用综述如下.
Abstract
Infantile epileptic spasm syndrome(IESS)is an age-dependent epileptic encephalopathy that onset within 3～12 months.Commonly used Anti-seizure medications(ASMs)have poor efficacy,low long-term control rate and high recurrence rate,and often leave behind sequelae such as developmental delay/intellectual disability,and autism spectrum disorders.At present,the first-line recommended treatments for IESS are Adrenocorticotropic hormone(ACTH),adrenocortical hormone and vigabatrin.If ineffective,other ASMs,ketogenic diets,and surgical treatments can be tried.This article will provide a review of the current status and related clinical applications of IESS treatment.
关键词
婴儿癫痫性痉挛综合征/治疗/预后Key words
Infantile epileptic spasm syndrome/Treatment/Prognosis引用本文复制引用
基金项目
江西省科技厅重点研发计划一般项目(20203BBGL73132)
出版年
2024
NETL
NSTL
万方数据