肠道菌群与色素沉着绒毛结节性滑膜炎之间的因果关系:基于孟德尔随机化分析
Causal relationship between gut microbiota and pigmented villonodular synovitis:a Mendelian randomization analysis
刘佳进 1缪长宏 1徐健康 1余伟杰 1陈继鑫 1唐好知 1刘爱峰1
作者信息
- 1. 天津中医药大学第一附属医院,天津 300381;国家中医针灸临床医学研究中心,天津 300381
- 折叠
摘要
目的 基于孟德尔随机化研究方法探究肠道菌群与色素沉着绒毛结节性滑膜炎之间的因果关系.方法 利用孟德尔随机化分析的3种主要方法,对211个肠道菌群类群与色素沉着绒毛结节性滑膜炎之间进行双向双样本孟德随机化分析,基于GWAS汇总数据以阐明两者间的因果关系.以逆方差加权分析方法(IVW)作为主要结果,其他方法均作为补充分析.最后使用Cochran's Q检验、MR-Egger回归法、MR-PRESSO法以及条件孟德尔随机化分析(cML-MA)验证结果的可靠性.结果 巴恩斯氏菌属(OR=3.12,95%CI:1.15～8.41,P=0.025)和瘤胃球菌科UCG010(OR=4.03,95%CI:1.19～13.68,P=0.025)的丰度升高可能增加色素沉着绒毛结节性滑膜炎的发病风险;毛螺菌科(OR=0.33,95%CI:0.12～0.91,P=0.032)、另枝菌属(OR=0.16,95%CI:0.05～0.53,P=0.003)、经黏液真杆菌属(OR=0.20,95%CI:0.06～0.61,P=0.005)、毛螺菌科FCS020(OR=0.38,95%CI:0.15～0.94,P=0.036)和瘤胃球菌科UCG014(OR=0.36,95%CI:0.14～0.94,P=0.037)的丰度升高与色素沉着绒毛结节性滑膜炎的发病风险降低相关.敏感性分析均支持该研究结果.反向孟德尔随机化分析并未发现两者间存在反向因果关联.结论 巴恩斯氏菌属和瘤胃球菌科UCG010可能是色素沉着绒毛结节性滑膜炎的潜在危险因素,毛螺菌科、另枝菌属、经黏液真杆菌属、毛螺菌科FCS020和瘤胃球菌科UCG014可能是潜在的保护因素,肠道菌群在其发病机制中的重要作用,提供了潜在干预措施的新思路.
Abstract
Objective To investigate the causal relationship between gut microbiota and pigmented villonodular synovitis using Mendelian randomization analysis.Methods We conducted a two-sample Mendelian randomization analysis to investigate the causal relationship between 211 gut microbiome taxa and pigmented villonodular synovitis based on GWAS summary data,with inverse variance weighted(IVW)analysis as the primary result and the other methods as supplementary analyses.The reliability of the results was tested using Cochran's Q test,MR-Egger regression,MR-PRESSO method and conditional Mendelian randomization analysis(cML-MA).Results The increased abundance of Barnesiella(OR=3.12,95%CI:1.15-8.41,P=0.025)and Rumatococcaceae UCG010(OR=4.03,95%CI:1.19-13.68,P=0.025)may increase the risk of pigmented villous nodular synovitis,and elevated abundance of Lachnospiraceae(OR=0.33,95%CI:0.12-0.91,P=0.032),Alistipes(OR=0.16,95%CI:0.05-0.53,P=0.003),Blautia(OR=0.20,95%CI:0.06-0.61,P=0.005),and Lachnospiraceae FCS020 group(OR=0.38,95%CI:0.15-0.94,P=0.036)and Ruminococcaceae UCG014(OR=0.36,95%CI:0.14-0.94,P=0.037)were all associated with a reduced risk of pigmented villonodular synovitis,which were supported by the results of sensitivity analyses.Reverse Mendelian randomization analysis did not reveal any inverse causal association.Conclusion Increased abundance of specific intestinal microorganisms is associated with increased or decreased risks of developing hyperpigmented villonodular synovitis,and gut microbiota plays an important role in the pathogenesis of this disease.
关键词
肠道菌群/色素沉着绒毛结节性滑膜炎/孟德尔随机化/因果关系Key words
gut microbiota/pigmented villonodular synovitis/Mendelian randomization/causality引用本文复制引用
基金项目
国家自然科学基金(81873316)
天津市科技计划项目(23KPXMRC00170)
天津市卫健委津门医学英才项目(TJSJMYXYC-D2-028)
出版年
2024
国家科技期刊平台
NSTL
万方数据