睡眠性状与特发性正常压力脑积水的因果关联:一项两样本双向孟德尔随机化研究
Causal relationship between sleep phenotype and idiopathic normal pressure hydrocephalus:a two-sample bidirectional Mendelian randomization study
钟帷韬 1李伟松 1李泽霖 1王强 1张旺明1
作者信息
- 1. 南方医科大学珠江医院神经外科中心小儿神经外科//广东省脑功能修复与再生重点实验室//国家临床重点专科//教育部工程技术研究中心,广东 广州 510282
- 折叠
摘要
目的 利用双向孟德尔随机化研究方法探索睡眠性状与特发性正常压力脑积水之间的因果关系.方法 采用GWAS catalog、芬兰公共数据库和MRCIEU GWAS数据库中8种睡眠性状的全基因组关联分析数据作为暴露,芬兰公共数据库中特发性正常压力脑积水(iNPH)的全基因组关联分析数据作为结局,使用逆方差加权法(IVW)作为主分析方法来评估睡眠性状与特发性正常压力脑积水之间的因果关系.敏感性分析方法采用Cochrane Q检验进行异质性检验和采用MR Egger-intercept检验来检测潜在的水平多效性.同时,进行反向孟德尔随机化分析特发性正常压力脑积水与睡眠性状的因果关联.结果 主分析方法IVW法显示经常白天小睡会增加iNPH的发病风险(OR=3.3393,95 CI%:1.0646-10.4742,P=0.0270).Cochrane Q检验显示结果无潜在的异质性、MR Egger-intercept检验显示结果无水平多效性(P>0.05).外部验证复现了这一结果(OR=2.5660,95 CI%:1.1680-5.6373,P=0.0189)、(OR=4.0424,95 CI%:1.5709-10.4024,P=0.0038).反向MR分析提示罹患iNPH不会影响睡眠性状.结论 白天小睡的频率和特发性正常压力脑积水存在因果关联,对于老年人群,减少每周白天小睡的频率有助于降低iNPH的发生风险.
Abstract
Objective To explore the causal relationship between sleep phenotype and idiopathic normal pressure hydrocephalus(iNPH)using two-sample bidirectional Mendelian randomization.Methods The exposure data including 8 sleep phenotypes used in this study were obtained from GWAS catalog,FinnGenR10 and MRCIEU GWAS.The outcome data for idiopathic normal-pressure hydrocephalus were obtained from FinnGen R10.We used the inverse-variance weighted(IVW)method to perform the principal analyses.Cochrane Q-statistics test was used to assess the heterogeneity and MR Egger-intercept test performed to evaluate the pleiotropy for sensitivity analyses.Results IVW result showed that frequent daytime nap was associated with higher odds of iNPH(OR=3.3393,95 CI%:1.0646-10.4742,P=0.0270).Cochrane Q-statistics test and MR Egger-intercept test showed that the MR analysis had no pleiotropy or heterogeneity(P>0.05).The external validation reproduced this result(OR=2.5660,95 CI%:1.1680-5.6373,P=0.0189;OR=4.0424,95 CI%:1.5709-10.4024,P=0.0038).Reverse Mendelian randomization suggested that iNPH did not have significant impact on sleep phenotype.Conclusion The frequency of daytime naps is causally associated with iNPH,and reducing the frequency of weekly daytime naps can reduce the risk of iNPH in the elderly population.
关键词
孟德尔随机化研究/睡眠性状/特发性正常压力脑积水/白天小睡Key words
Mendelian randomization/sleep phenotype/idiopathic normal pressure hydrocephalus/day nap引用本文复制引用
基金项目
广东省医学基金(A2023114)
广州市科技计划项目(2023A04J2425)
南方医科大学珠江医院院长基金(yzjj2022qn16)
出版年
2024
国家科技期刊平台
NSTL
万方数据