Differences in sleep structural parameters and their relationship with daytime brain function in patients with obstructive sleep apnea at different ages
Differences in sleep structural parameters and their relationship with daytime brain function in patients with obstructive sleep apnea at different ages
OBJECTIVE To explore the differences in sleep structure parameters and the relationship with brain functional status in patients with obstructive sleep apnea(OSA) at different ages. METHODS A total of 200 OSA patients admitted to our hospital from April 2019 to May 2022 were selected as the study objects,and the patients were divided into young group(<40 years old,n=67),middle-aged group(41-65 years old,n=78),and elderly group(>65 years old,n=55) according to age,and the clinical data of the three groups were compared. Sleep structure parameters were got from polysomnography(PSG);Resting state EEG(rs-EEG) was used to measure the daytime brain function. The relationship between sleep structure parameters and daytime brain function status was analyzed using Logistic regression. Receiver operating characteristic curve(ROC) was used to analyze the diagnostic value of PSG results and brain function status in different age groups. RESULTS The frequency of fast wave sleep,N2 phase ratio,REM phase ratio,brain chaos index,external focus index and external focus index in the middle-aged group were higher than those in the young group and the old group. The number of slow wave sleep,endogenous anxiety index and reaction speed index in the middle-aged group were lower than those of young group,and the differences were statistically significant(P<0.05). Multi-factor results showed that the number of slow-wave sleep,the number of fast-wave sleep,the ratio of N2 phase sleep and the ratio of REM sleep were independent risk factors for the change of daytime brain function status in OSA patients of different ages. The number of slow wave sleep was negatively correlated with brain chaos index,reaction speed index and internal focus index. The frequency of fast wave sleep and the ratio of N2 phase sleep were positively correlated with brain chaos index and external focus index. The REM phase ratio was positively correlated with the brain chaos index,endogenous anxiety index and internal focus index. In the middle-aged group,when AHI≥5,≥15 and ≥30 times/h,the frequency of fast wave sleep,N2 phase sleep ratio and REM phase ratio had highly predictive values for the diagnosis and evaluation of severity of OSA. In the young group and the elderly group,when AHI≥30 times/h,the frequency of fast wave sleep can highly predict the diagnostic value of moderate and severe OSA in the young group,and the N2 phase sleep ratio and REM phase ratio can highly predict the diagnostic value of moderate OSA in the elderly group. CONCLUSION The sleep and brain status of OSA patients showed significant differences among different age groups. Patients in middle age group had the worst sleep quality and significant changes in daytime brain function status. The number of Slow-wave sleep,N2 phase sleep ratio,and REM phase sleep ratio have the highest diagnostic values for daytime brain function.
关键词
睡眠呼吸暂停,阻塞性/年龄/睡眠结构参数/日间脑功能状态
Key words
Sleep Apnea,Obstructive/Age/sleep architecture parameters/brain brain status
维普
万方数据