Objective:To evaluate the distribution and compliance rate of vancomycin trough concentrations in neonates under different guidelines recommended,explore the possibility of improving the compliance rate,so as to provide references for clinical adjustment of dosing regimens.Methods:Clinical data of 128 neonates received vancomycin treatment admitted into the Neonatology Department of Women and Children's Hospital Affiliated to Xiamen University from Nov.2016 to Mar.2021 were retrospectively analyzed,and the compliance rate of vancomycin trough concentrations in different dosing regimens and dosing intervals was evaluated.Results:Among 128 infants,when the goal trough concentration of vancomycin was from 5 to 15 mg/L,the compliance rate was 56.25％(72 cases),and when the goal trough concentration was from 10 to 20 mg/L,the compliance rate was 50.78％(65 cases).There was no significant difference in compliance rate of vancomycin trough concentrations between premature and term neonates.There was no significant difference in compliance rate of vancomycin trough concentrations between dosing regimen recommended according to the drug instructions and other dosing regimens.When the goal trough concentration of vancomycin was from 5 to 15 mg/L,the compliance rate of 12-h interval group(68.18％)was significantly higher than that of 8-h interval group(43.55％).Conclusion:Based on the goal trough concentration of vancomycin in neonates recommended by the new guideline(from 5 to 15 mg/L),the previous empiric dosing regimens for neonates may need to be readjusted to improve the compliance rate of goal trough concentration.
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万方数据