我院双嘧达莫在儿童患者的临床应用分析
Clinical Application of Dipyridamole in Children in Our Hospital
刘翌 1唐盈 1陈章华 1刘明 1莫小兰 1张玉霞1
作者信息
- 1. 广州市妇女儿童医疗中心,广州 510623
- 折叠
摘要
目的:分析双嘧达莫在儿童中的临床用药情况,为该药在儿童人群的合理应用及超说明书用药提供参考.方法:抽取广州市妇女儿童医疗中心2016年2月22日至2022年5月29日使用双嘧达莫的18岁以下患儿的病历资料,对患儿基本信息、疾病诊断、用药时间和剂量等进行分析.结果:共抽出符合条件的患儿2381例,其中男1 567例,女814例.0～1岁患儿250例,＞1～3岁患儿446例,＞3～12岁患儿1 483例.双嘧达莫在我院主要应用于肾脏疾病、消化道疾病、呼吸道疾病、心血管疾病和血液疾病等.患儿用药时间多为30天内,连续用药日剂量为12.5～250.0 mg,临时用药日剂量为3.0～250.0 mg,日剂量与患儿年龄呈正相关,但相关性较弱.该院双嘧达莫超适应证用药部分有指南、文献或临床试验证据,超年龄用药有证据支持,且符合建议用量.结论:双嘧达莫在儿科特定疾病的临床使用,未发现不良反应记录.
Abstract
Objective:To analyze the clinical application of dipyridamole in children,so as to provide reference for rational application and off-label use of dipyridamole in children.Methods:Medical records of patients under 18 years with dipyridamole from Feb.22nd,2016 to May 29th,2022 in Guangzhou Women and Children's Medical Center were extracted.The basic information,disease diagnosis and duration of medication dosage were analyzed.Results:A total of 2,381 medical records were extracted,including 1,567 males and 814 females.There were 250 children aged from 0 to 1 year,446 children aged from 1 to 3 years,and 1,483 children aged from＞3 to 12 years.The main diagnosis were renal diseases,gastrointestinal diseases,respiratory diseases,cardiovascular diseases and hematological diseases.Patients were mostly administered within 30 d,with continuous daily doses ranging from 12.5 to 250.0 mg and temporary daily doses ranging from 3.0 to 250.0 mg.Daily doses were positively correlated with patients'age,yet the correlation was weak.The off-label indication of dipyridamole at the hospital was partially supported by guidelines,literature or clinical trial evidence.The off-label age was supported by evidence,and was consistent with the recommended dosage.Conclusion:No adverse drug reactions have been documented for the clinical application of dipyridamole for specific diseases in pediatrics.
关键词
双嘧达莫/儿童用药/临床数据分析Key words
dipyridamole/pediatric drug use/clinical data analysis引用本文复制引用
出版年
2025
国家科技期刊平台
NSTL
万方数据