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肠道菌群与胰腺癌发生发展的研究进展

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胰腺癌发病率在世界范围内不断上升,缺乏早期筛查、诊断以及有效治疗的手段.此文总结了肠道菌群对胰腺癌发生、发展的影响及可能的作用机制,以及应用抗生素、粪菌移植等方式调节肠道菌群组成在胰腺癌综合治疗中相关研究,以求为胰腺癌的早期诊断和精准治疗带来新的思路.
Research advances of gut microbiota and pancreatic carcinogenesis
Pancreatic cancer(PC)is one of the most malignant tumors in digestive tract.It lacks early screening and diagnostic methods and treatment outcomes are disappointing.Its incidence rate is rising all over the world.This review focused upon the effects of intestinal flora on the occurrence and development of PC and discussed its possible mechanism of action.Other topics included dosing of antibiotics,fecal bacteria transplantation and other measures for regulating the composition of intestinal flora in the comprehensive treatment of PC.It was intended to offer new rationales for an early diagnosis and accurate treatment of PC.

Pancreatic cancerGut microbiotaGut microbiota dysbiosisMechanism

张孟哲、张正乐、陶京

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武汉大学人民医院胰腺外科,湖北 武汉 430060

胰腺癌 肠道菌群 肠道菌群失调 机制

2024

腹部外科
中华医学会武汉分会

腹部外科

CSTPCD
影响因子:0.615
ISSN:1003-5591
年,卷(期):2024.37(1)
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