Current status of classification and comprehensive treatments for intrahepatic cholangiocarcinoma
Intrahepatic cholangiocarcinoma(ICC)is a highly malignant primary liver cancer with the second highest incidence of primary liver cancer.Surgical resection remains a sole cure for ICC.And due to great invasiveness,its prognosis remains poor.Most patients have lost the chance of surgery when the disease is initially detected.And there is still a high risk of postoperative recurrence.In recent years,transarterial chemoembolization,hepatic arterial infusion and chemoradiotherapy have achieved some successes of ICC treatment.Liver transplantation has gradually been actively explored for early-stage ICC.Currently targeted therapy and immunotherapy are also gradually emerging.Comprehensive and personalized treatments have been formulated with surgery as a mainstay along with a combination of various treatments.With rapid advancements of gene sequencing technology and in-depth researches on tumor microenvironment,molecular classification has also become a recent hotspot.However,some controversial protocols should be validated by large-scale clinical trials.This review summarized the latest advances of molecular classification,local/systemic treatment of ICC and guiding role of molecular classification for targeted therapy and other therapeutics.
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