Current status and recent advances in the application of mini-invasive gastrectomy after neoadjuvant immunotherapy for locally advanced gastric cancer
Neoadjuvant immunotherapy has become an effective modality for enhancing the therapeutic efficacy of locally advanced gastric cancer(LAGC).In modern era of mini-invasive surgery,favorable tumor response,treatment-related adverse events and potential impact on perioperative tissues from neoadjuvant immunotherapy are correlated closely with perioperative safety and long-term survival.Current evidence suggests that mini-invasive gastrectomy after neoadjuvant immunotherapy is both safe and feasible with comparable short-term outcomes and long-term survival despite intraoperative difficulties.On this basis,clinical cooperation should be actively promoted for addressing such key issues as timing of surgery after neoadjuvant immunotherapy,individualized lymph node dissection and function-preserving mini-invasive gastrectomy to standardize and expand the indications for mini-invasive gastrectomy after neoadjuvant immunotherapy for LAGC.
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