Values of fibrinogen and interleukin-6 in assessing the severity of acute cholecystitis
Objective To explore the values of fibrinogen(FIB)and interleukin-6(IL-6)in assessing the severity of acute cholecystitis(AC).Methods From October 2021 to October 2023,165 AC patients within 72 hours of onset were recruited.According to the severity of AC,they were assigned into two groups of mild cholecystitis(n=78)and moderate/severe cholecystitis(n=87).The levels of FIB and IL-6 were detected and receiver operating characteristic(ROC)curves plotted for assessing the value of FIB/IL-6 for the severity of AC.Results The levels of FIB and IL-6 were significantly higher in moderate/severe cholecystitis group than those in mild cholecystitis group.And the inter-group difference was statistically significant(P<0.05).ROC curve indicated that area under the curve(AUC)predicted by FIB was 0.760.The optimal diagnostic point was 3.455 g/L with a sensitivity of 85.1%and a specificity of 55.1%.And AUC predicted by IL-6 was 0.752.The optimal diagnostic point was 83.365 pg/ml with a sensitivity of 48.3%and a specificity of 100%.AUC of FIB plus IL-6 in predicting the severity of AC was 0.845.It was significantly higher than AUC predicted by each alone.The sensitivity was 67.8%and the specificity 84.6%.Conclusion The levels of FIB and IL-6 spike markedly in moderate/severe cholecystitis.Both parameters have higher values in judging the severity of AC.And a combination of both is even better.
FibrinogenInterleukin-6Acute cholecystitisOrder of severity
NETL
NSTL
万方数据
