Current researches of ω-3 polyunsaturated fatty acids and postoperative primary liver cancer patients
The global incidence and mortality of primary liver cancer(PLC)are relatively high.Although 5-year survival rate of patients with early detection and curative treatment surpasses 60%,postoperative stress,complications and tumor recurrence seriously affect the quality-of-life and survival of patients post-operation.Due to their functions of regulating lipid metabolism,lowering oxidative stress and maintaining intestinal health,ω-3 PUFAs were not only extensively applied as a commercial food supplement for preventing the development of liver cancer but also as an active component of parenteral nutrition fat emulsion in postoperative patients.Existing studies have shown that postoperative application of omega-3 PUFAs in PLC patients could blunt inflammatory response,protect liver function,reduce the occurrence of infection and thus shorten the length of hospital stay.In patients at a high risk for recurrence,long-term use of omega-3 PUFAs or in combination with adjuvant therapy offered beneficial effects of mproved adjuvant therapy and prevention of adverse toxic effects.However,another study contradicted the previous findings.Thus the mechanism of action of omega-3 PUFAs is so complex that many regulatory links remain to be further elucidated.Its impact on clinical parameters of postoperative PLC patients should be confirmed with a large amount of data.
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