Current researches of photodynamic therapy for unresectable extrahepatic cholangiocarcinoma
The most common symptom of extrahepatic cholangiocarcinoma is jaundice.Due to a lack of early special symptoms,most patients become inoperable at the time of an initial diagnosis.The prognosis of patients with advanced or unresectable extrahepatic cholangiocarcinoma is generally poor owing to ineffective palliative therapy.Stenting for bile duct drainage has been a standard procedure of relieving symptoms and improving quality-of-life.However,no significant improvement of median survival time is noted.Photodynamic therapy is a combination of photosensitizer and laser light.In conjunctions with biliary stenting,surgery and chemoimmunotherapy,targeted accumulation of photosensitizer in tumor tissues and accurate activation by laser light may further boost the curative efficacies.With bright application prospects,it may be employed as an effective local therapy for unresectable extrahepatic cholangiocarcinoma.
Bile duct cancerPalliative therapyPhotodynamic therapyUnresectable
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