Evaluations of efficacy of metabolic and bariatric surgery in obese patient with polycystic ovary syndrome
Objective To explore the effects of different types of metabolic and bariatric surgery on body weight(BW),body mass index(BMI),ovarian morphology,follicle number,menstrual cycle,androgens and anti-mullerian hormone(AMH)in obese patients with polycystic ovary syndrome(PCOS).Methods From February 2021 to June 2023,70 obese patients with PCOS and 60 obese patients without PCOS admitted were assigned into two groups.For obese patients with PCOS,sleeve gastrectomy(SG,n=35)and Roux-en-Y gastric bypass(RYGB,n=35)were performed.And for obese patients without PCOS,SG(n=30)and RYGB(n=30)were performed.The changes of BW,BMI,ovarian morphology,follicle number,menstrual cycle and androgen/AMH level of two groups were recorded.Results BW and BMI at post-operation were significantly lower than those at pre-operation.Ovarian volume and follicle number declined markedly,menstrual cycle became obviously shortened and AMH/androgen level dropped significantly as compared with those at pre-operation.SG/RYGB demonstrated marked weight loss in both PCOS and non-PCOS obese patients and no significant difference existed in weight loss effect.And RYGB was superior to SG in long-term weight loss,long-term regulation of follicle volume/quantity,long-term improvement of androgen level,short-term adjustment of menstrual cycle and lowering the level of AMH.Conclusion SG/RYGB may significantly relieve PCOS in obese patients.
万方数据
维普
