Relationship between TyG index and prognosis of colorectal cancer surgery
Objective To evaluate the correlation between triglyceride glucose(TyG)index and postoperative prognosis in colorectal cancer(CRC)patients.Methods From January 2012 to December 2015,376 CRC patients undergoing radical resection were retrospectively reviewed.R Project for Statistical Computing(Version 4.3.3)was utilized for constructing a nomogram prediction model and its differentiation and accuracy were evaluated by calculating consistency index(C-index)and plotting calibration curves.From January 2016 to December 2018,the clinical data of 137 patients undergoing radical resection for rectal cancer were collected for external validation.Results TyG index,preoperative age,prognostic nutritional index(PNI)score,tumor stage,differentiation degree and postoperative complications were independent prognostic factors(all P＜0.05).According to the results of log-rank test,risk ratio between high TYG and low TyG index groups was 1.847(95％CI:1.205-2.831,P=0.010 9)and C-index of nomogram model was 0.742 in training cohort.Calibration curve indicated that survival rate as predicted by nomogram accorded well with actual survival rate.External verification was conducted by time period verification.C-index of column-line was 0.769 in verification cohort.Calibration curve indicated that column-line predicted survival rate accorded well with actual survival rate.Conclusion TyG index is an independent risk factor for the postoperative prognosis of CRC patients.The higher the TyG index,the worse the postoperative prognosis of patients.
万方数据
维普
