Research Progress of Circulating Tumor Cell Detection Based on Fluorescence Method
Circulating tumor cells(CTCs)are cells that are shed from the primary or metastatic site of a malignant tumor and circulate through the bloodstream to reach the body.Therefore,the presence of CTCs in vivo can reflect the occurrence and development of tumors,which is crucial for the diagnosis and prognosis of tumors.However,there are still many challenges to achieving high purity capture and post-capture CTCs inactivation blocking.Among the schemes developed for selective separation of CTCs,fluorescence method has an important application prospect in non-invasive detection and rapid detection because of its high sensitivity,high resolution and simple operation.Compared with previous CTCs research reviews,this paper describes the whole process of CTCs from in vitro capture to in vivo capture to downstream analysis in detail,and systematically and detailedly summarizes the complete diagno-sis and treatment process of CTCs,providing new ideas for current research.This is of great significance for the diag-nosis and treatment of early circulating tumor cells.
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