Construction and Properties of Colorimetric Zn2+Fluorescent Probe Based on Naphthofuran
Zinc ion(Zn2+),as a vital trace metal element for the human body,playing a key role in maintaining the normal physiological function of the human body,energy conversion,metabolism and signal transmission,etc.The detection and monitoring of Zn2+in the body was of great significance for the prevention and treatment of related diseases.A colorimetric responsive fluorescent probe(SPA)for Zn2+was designed and synthesized by condensation of naphthalene and[2,1-b]furan-2-carbohydrazide with 4-(diethylamino)salicyl aldehyde.The fluorescence of probe SPA was greatly enhanced and the wavelength was obviously red-shifted after the identification of Zn2+.The response mechanism of probe SPA to Zn2+was investigated by HR-MS.The detection limit of Zn2+recognized by probe SPA can be as low as 1.13 nmol/L.The probe SPA has been successfully applied to confocal imaging of Zn2+in HeLa cells and fluorescence imaging of Zn2+in live mice in vivo.
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