发光学报2024,Vol.45Issue(12) :2054-2065.DOI:10.37188/CJL.20240223

碳点药物载体在肿瘤治疗中的应用进展

Advances in Carbon Dot-based Drug Carriers for Tumor Therapeutic Applications

李乃辉 张清梅 杨国庆 程泽伟 杜秀娟 孙凌翔 王伟 李冰
发光学报2024,Vol.45Issue(12) :2054-2065.DOI:10.37188/CJL.20240223

碳点药物载体在肿瘤治疗中的应用进展

Advances in Carbon Dot-based Drug Carriers for Tumor Therapeutic Applications

李乃辉 1张清梅 1杨国庆 1程泽伟 1杜秀娟 1孙凌翔 2王伟 3李冰2
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作者信息

  • 1. 太原科技大学 应用科学学院,山西 太原 030024
  • 2. 山西医科大学 口腔医院,山西 太原 030001
  • 3. 山西医科大学第二医院 妇产科,山西 太原 030001
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摘要

碳点是一种新型的零维碳基纳米材料,具有小尺寸、低毒性以及表面易于功能化等诸多优点.碳点的出现为靶向递送药物实现癌症治疗提供了新思路.本综述系统阐述了碳点作为载体在药物递送方面的应用进展.首先,阐述了碳点的分类以及合成方法;其次,总结了国内外近年来基于碳点的不同种类药物(化疗药物、光敏剂、光热剂等)的递送研究进展;最后,对现阶段面临的挑战和应用前景进行了探讨,以期为从事碳点在药物递送方面研究的科研人员提供一些思路.

Abstract

Carbon dots are a new type of zero-dimensional carbon-based nanomaterials with many advantages,such as small size,low toxicity and easy surface functionalization.The emergence of carbon dots provides new ideas for targeted delivery of drugs to achieve cancer therapy.This review systematically describes the progress of the applica-tion of carbon dots as carriers for drug delivery.Firstly,the classification and synthesis methods of carbon dots are described.Secondly,the research progress of different kinds of drug delivery(chemotherapeutic drugs,photosensi-tizers,photothermal agents,etc.)based on carbon dots at home and abroad in recent years is summarized.Finally,the challenges and the application prospects are discussed,which is intended to provide some ideas for the research-ers who are engaged in the research of carbon dots in the field of drug delivery.

关键词

碳点/药物递送/抗癌/光热治疗/光动力治疗/协同治疗

Key words

carbon dots/drug delivery/anticancer/photothermal therapy/photodynamic therapy/synergistic therapy

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出版年

2024
发光学报
中国物理学会发光分会,中国科学院长春光学精密机械与物理研究所

发光学报

CSTPCD北大核心
影响因子:1.301
ISSN:1000-7032
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