Establishment and Analysis of GC-MS/MS Method for Detection of Flumidazole and its Metabolites in Grape
Using QuEChERS method combined with EMR adsorbent as pretreatment method and multiple reactive ion moni-toring mode by mass spectrometry(dMRM),a gas chromatography-triple quadrupole mass spectrometry(GC-MS/MS)method was established for the analysis of flumidazole and its metabolites in grape.The result shows that the linearity of flumidazole and its metabolites was good in the range of 1-1 000 µg/L,the correlation coefficient was above 0.99,the detec-tion limit was 0.001 mg/kg,the recovery was 82.1％-90.4％,and the relative standard deviation(RSD)was 2.04％-3.96％.This method has the characteristics of simplicity,speed,good repeatability,and high accuracy,with efficient and fast opera-tion.It is suitable for the qualitative and quantitative detection of fluconazole and its metabolites in grapes.
gaschromatography-triple quadrupole mass spectrometryGrapesFlumidazole and its metabolitesMulti-ion reaction monitoring model
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