In order to understand the response mechanism of the growth of Neyraudia reynaudiana in Pb contaminated mining area, a pot culture experiment was carried out to study physiological indexes of N. reynaudiana under different Pb stress. The result showed that low Pb concentration ( 250 mg·kg-1 ) could significantly boost plant growth such as plant height, length and area of root, and whole plant biomass compared with CK. High Pb concentration (500, 750 mg·kg-1) gradually inhibited the growth trend of N. reynaudiana while the performance, including leaf length, volume and diameter of root, were still stonger than that of CK ( P<0.05) . Malondialdehyde ( MDA) content increased dramatically, while superoxide dismutase ( SOD) , peroxidase ( POD) , and catalase ( CAT) were decrease under the growing Pb stress. Pb stress didn′t show much impact on the content of chlorophyll a and b. Transfer coefficient was bigger than 1 suggesting N. reynaudiana had the ability to move Pb. By adjusting organs morphology, promoteing root development and root shoot ratio, keeping the speed of photosynthesis and transportation stable, N. reynaudiana had showed its adaptability to limited Pb stress that had a application potential in the remediation of Pb polluted soil.